| President of Ghana to open Fourth Ordinary Session of the Fifth Parliament of the Pan-African Parliament, 24 May | 24 May 2021 | Conferences, summits, seminars and workshops |
| Minister Blade Nzimande briefs media before the Science and Innovation Budget Vote, 18 May | 18 May 2021 | Media briefings |
| President Cyril Ramaphosa participates in Summit on Financing of Africa, 16 to 17 Mayn Economies | 16 May 2021 to 17 May 2021 | Government activities |
| Premier Alan Winde and MEC Nomafrench Mbombo launch Phase 2 of its mass Covid-19 vaccination programme for people over 60 in the Western Cape, 17 May | 17 May 2021 | Government activities |
| Premier Chupu Stanley Mathabatha launches second phase of COVID-19 vaccination of citizens aged 60 years and above in Limpopo, 17 May | 17 May 2021 | Government activities |
| Employment and Labour registers work seekers in Nkomazi Municipality on Employment Services of South Africa database, 17 to 21 May | 17 May 2021 to 21 May 2021 | Government activities |
| MEC Madoda Sambatha conducts Covid-19 vaccination drive, 17 to 18 May | 17 May 2021 to 18 May 2021 | Government activities |
| Minister Aaron Motsoaledi engages Eldorado Park community on home affairs and other government services, 15 May | 15 May 2021 | Government activities |
| Student Financial Aid Scheme briefs media on new Board of Directors, 18 May | 18 May 2021 | Government activities |
| Deputy Minister Dikeledi Magadzi conducts career expo in Mpumalanga, 17 May | 17 May 2021 | Government activities |
