| World Trauma Day 2021 |
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| World Spine Day 2021 |
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| Global Handwashing Day 2021 |
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| World Day for Audiovisual Heritage 2021 |
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| Premier Alan Winde delivers special address to the province, 22 Oct |
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| World Arthritis Day 2021 |
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| World Book and Copyright Day 2021 |
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| International Mother Earth Day 2021 |
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| World Food Day 2021 |
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| International Day for Mine Awareness and Assistance in Mine Action 2021 |
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| Child Protection Week 2021 |
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| International Day of Remembrance of the Victims of Slavery and the Transatlantic Slave Trade 2021 |
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| International Day of Rural Women 2021 |
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| World Water Day 2021 |
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| Human Rights Day 2021 |
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| International Day for the Elimination of Racial Discrimination 2021 |
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| World Poetry Day 2021 |
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| KwaZulu-Natal wishes Minister Zweli Mkhize and his wife a speedy recovery from Coronavirus COVID-19 |
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| World Consumer Rights Day 2021 |
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| Commonwealth Day 2021 |
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