| World Sight Day 2021 |
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| Water and Sanitation raises awareness on hand washing and fighting Coronavirus COVID-19 |
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| World Mental Health Day 2021 |
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| Partnership against HIV/AIDS Anniversary 2021 |
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| Deputy Minister Fish Mahlalela engages Thabo Mofutsanyana District Municipality on activating rural tourism development, 16 Oct |
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| Breast Cancer Awareness Month 2021 |
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| Mental Health Awareness Month 2021 |
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| Basic Education marks Global Handwashing Day, 15 Oct |
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| National Inherited Disorders Day 2021 |
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| World Rabies Day 2021 |
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| Minister Thulas Nxesi on progress made on measures to mitigate the impact of the Coronavirus COVID-19 pandemic on employment and labour |
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| World Environmental Health Day 2021 |
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| Department of Women, Youth and Persons with Disabilities hosts roundtable discussion on process, currently underway, to form the Board of Trustees, 14 Oct |
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| Eye Care Awareness Month 2021 |
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| World Alzheimer's Day 2021 |
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| MEC Nomusa Dube-Ncube: Employment and Labour virtual sitting of the National Council of Provinces |
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| World Suicide Prevention Day 2021 |
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| World Foetal Alcohol Syndrome Day 2021 |
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| Minister Stella Ndabeni-Abrahams visits Traditional Leaders and communities in Tzaneen, 15 and 16 Oct |
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| Government on passing away of Dr Vuyokazi Mahlati Chairwoman of the Advisory Panel on Land Reform and Agriculture |
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